Plant communities change via disturbances and exotic invasions. Disturbance outcomes through secondary succession change which species characterize communities. The objective of this research was to investigate community shifts in varying disturbance combinations. A strip-strip block design was established in 1996 in a successional old-field at Touch of Nature Environmental Center (Makanda, IL). Parallel strips were randomly assigned to blocks crossing fertilizer (control, five-year, and annual application) and mowing (control, spring, spring-fall) treatments. Species abundance was recorded for plots within seven blocks during nine surveys over 22 years. Nonmetric-multidimensional scaling (NMDS) displayed species and vectors displayed trajectories based on species richness, exotic invasive cover, and surveys. Confidence ellipses circumscribe plots sharing similar treatments. Repeated-measures permutational analyses of variance (PERMANOVA) and tests for homogeneity of dispersion (PERMDISP) tested the effects of treatments and their interactions. Post-hoc pairwise-Adonis tests characterized pairwise contrasts among treatment levels. Indicator species analyses (ISA) identified species significantly characterizing treatments and surveys. PERMANOVA and PERMDISP showed significant interactive effects of treatments on community composition (F4,617=1.637; p=0.01) and dispersion (F8,617=23.07; p=0.001). This interaction was evident in the NMDS ordination, where confidence ellipses for treatments overlapped for three fertilizer treatments and spring and spring-fall mowing treatments were separate to un-mowed plots regardless of fertilizer treatment.  Pairwise-Adonis indicated significantly different combinations of treatment levels occurred where 28 of 36 pairs of treatment combinations were significantly different to each other. Indicator species analyses identified 50 indicator species for at least one treatment during surveys. Six exotic invasive indicator species displayed unique patterns of dominance over surveys and treatment combinations. Over time, exotic invasives became more frequently indicator species (especially in mowing treatments). Treatment levels without exotic invasives as indicators for any survey were five-year and annual fertilizer treatments. Over secondary succession some combinations of disturbances are more susceptible to dominance by exotic invasives.