Scientific and information visualization have long offered powerful approaches for helping people graphically represent, explore, and understand our universe. Our group investigates tangible visualization. Here, tangible interfaces (which support interaction through systems of computationally-mediated physical artifacts) are used to interactively represent complex systems. We approach this research from two perspectives: studying and engaging specific application domains; and developing underlying architectures supporting realizations of tangible visualization. We target two primary application areas: interactive computational science, technology, engineering, arts, and mathematics (ICy STEAM) and cultural computing. We will describe ICy STEAM efforts in computational comparative genomics, and cultural computing examples from LSU CCT's Cultural Computing focus area (with 15 faculty spanning our Schools of Art, EECS, ISDS, Mass Communications, and Music).