BIOE 500 Spring 2026 - Prof. Edward Guo
From Wawrzyniec Dobrucki
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From Wawrzyniec Dobrucki
Bone Bioengineering: Microstructure, Mechanics, Mechanobiology, and Beyond
Abstract: Bone Bioengineering has a basic science and clinical significance in many medical fields, such as osteoporosis, osteoarthritis, or intervertebral disc degeneration. I will highlight our development of three-dimensional imaging analysis and modeling techniques for trabecular bone microstructure, its applications in basic science research of bone mechanics, and clinical applications in osteoporosis and osteoarthritis. We will discuss bone microstructural phenotypes in different races and their implications in genetic and precision medicine, anthropology, evolution, and mechanobiology of the skeletons. In parallel to these developments, we will also showcase how mechanobiology links to bone microstructure and mechanics.
Biography: X. Edward Guo is the Stanley Dicker Professor of
Biomedical Engineering and Professor of Medical Sciences (in Medicine) at
Columbia University. Born and raised in China, he earned his B.S. in Applied
Mechanics from Peking University. He pursued graduate training in the United
States and received his M.S. (1990) and Ph.D. (1994) in Medical Engineering and
Medical Physics from the Harvard–MIT Division of Health Sciences and
Technology. He completed postdoctoral training in the Orthopaedic Research Laboratories
at the University of Michigan.
Professor Guo joined Columbia University in 1996 as an Assistant Professor and
was promoted to Associate Professor with tenure in 2003, Full Professor in
2007, and named Stanley Dicker Professor in 2018. He directs the Bone
Bioengineering Laboratory at Columbia, where his research focuses on bone
micromechanics, computational biomechanics, and mechanobiology.
His honors include the NSF CAREER Award, NIH National Research Service Award,
Young Investigator Recognition Award from the Orthopaedic Research Society, the
Christopher R. Jacobs Award from BMES, and the Adele L. Boskey Esteemed Award
from ASBMR. He is an elected Fellow of AIMBE, ASME, BMES, ASBMR, ICORS, IAMBME,
and ORS. Professor Guo served as Chair of Columbia’s Department of Biomedical
Engineering from 2017 to 2023 and founded the Northeast Bioengineering League,
serving as its inaugural President.